Occasionally we get sticky USB problems when something goes wrong during a device’s initial configuration. To remedy this, you sometimes have to remove the instance of the USB device. This tool: http://www.ftdichip.com/Support/Utilities/CDMUninstaller_v1.4.zip
can be used to remove all memory of previously connected Signal Hounds.
Launch the GUI version, leave teh VID at 0403, change the PID to 6010, click “Add”, and then click “remove devices”. Then re-install the USB driver, connect your device, wait for the “searching for updated driver” to finish (1-2 minutes sometimes), and then launch Spike.